NTRK1 / TrkA

neurotrophic tyrosine kinase, receptor, type 1

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

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Products

Proteins (16)

Type

Over-Expression Lysate (6)

Recombinant (10)

Target

NTRK1 / TrkA (16)

Publications

No (16)

Tag

Fc (1)

Fc, C-terminus (1)

Fc-6His, C-terminus (1)

His (2)

His,C-terminus (3)

Myc-DDK (Flag) (7)

Species

Human (9)

Mouse (2)

Rat (2)

Source

293T Cells (3)

E. coli (1)

HEK 293 Cells (9)

Human Cells (3)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (8)

Biologically Active

Biologically active (1)

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Human NTRK1 / TrkA Protein (Recombinant) - LS-G27180

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

65~85 kDa (SDS-PAGE)

Price:

50 µg/$342; 10 µg/$253; 1 mg/$2,449

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Human NTRK1 / TrkA Protein (Recombinant Fc-6His, C-terminus) (aa33-384) - LS-G97735

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66 kDa

Price:

100 µg/$721

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Human NTRK1 / TrkA Protein (Recombinant His) (Pro194-Glu413) - LS-G97732

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

26 kDa

Price:

100 µg/$721

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NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99267

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.8 kDa

Price:

100 µg/$710

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Human NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81300

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

83.8 kDa

Price:

20 µg/$215

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Human NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81301

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$215

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Human NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81302

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.3 kDa

Price:

20 µg/$215

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Human NTRK1 / TrkA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68042

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

20 µg/$1,107

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NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117928

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.3 kDa

Price:

100 µg/$710

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NTRK1 / TrkA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121832

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.7 kDa

Price:

100 µg/$710

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Rat NTRK1 / TrkA Protein (Recombinant His,C-terminus) (Met1-Pro418) - LS-G138196

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.7 kDa

Price:

100 µg/$721

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Mouse NTRK1 / TrkA Protein (Recombinant His,C-terminus) (Met1-Gly420) - LS-G138124

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43.7 kDa

Price:

100 µg/$721

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Rat NTRK1 / TrkA Protein (Recombinant Fc, C-terminus) (Met1-Pro418) - LS-G138197

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

69.2 kDa

Price:

100 µg/$721

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Human NTRK1 / TrkA Protein (Recombinant His,C-terminus) (Met1-Pro382) - LS-G138044

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.5 kDa

Price:

100 µg/$721

Select

Human NTRK1 / TrkA Protein (Recombinant His) (Pro285-Glu413) - LS-G97734

Source:

E. coli

Tag:

His

Molecular Weight:

15.1 kDa

Price:

100 µg/$721

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Mouse NTRK1 / TrkA Protein (Recombinant Fc) (Met1-Gly420) - LS-G98227

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

69.2 kDa

Price:

100 µg/$721

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