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NT5E / eNT / CD73

5'-nucleotidase, ecto (CD73)

NT5E / eNT / CD73 is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: 5'-nucleotidase, ecto (CD73)
Synonyms: NT5E, 5-nucleotidase, ecto (CD73), 5'-nucleotidase, 5 nucleotidase (CD73), 5-NT, 5-nucleotidase, 5'-nucleotidase, ecto (CD73), CD73, CD73 antigen, E5NT, Ecto-5-nucleotidase, ENT, EN, NT, Purine 5-Prime-Nucleotidase, NT5, NTE
Target Sequences: NM_002526 NP_002517.1 P21589

Publications (6)

1
Hypoxia-inducible factor-1-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor. Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4367-74. [PubMed:21357264] Related Antibodies: LS-B3428.
2
Simultaneous Overexpression of Functional Human HO-1, E5NT and ENTPD1 Protects Murine Fibroblasts against TNF-a-Induced Injury In Vitro. Cinti A, De Giorgi M, Chisci E, Arena C, Galimberti G, Farina L, Bugarin C, Rivolta I, Gaipa G, Smolenski RT, Cerrito MG, Lavitrano M, Giovannoni R. PloS one. 2015 10:e0141933. (WB; Human) [Full Text Article] [PubMed:26513260] [PMC:PMC4626094]
3
Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia. Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks MJ, Blackburn MR, Kellems RE, Xia Y. Circulation. 2015 131:730-41. (IHC; Mouse) [Full Text Article] [PubMed:25538227] [PMC:PMC4751998] Related Antibodies: LS-B2943.
4
Co-expression of functional human Heme Oxygenase 1, Ecto-5'-Nucleotidase and ecto-nucleoside triphosphate diphosphohydrolase-1 by self-cleaving" 2A peptide system.". Marco De Giorgi, Alessandro Cinti, Iwona Pelikant-Malecka, Elisa Chisci, Marialuisa Lavitrano, Roberto Giovannoni, Ryszard T Smolenski. Plasmid. 2015 May;79:22-9. [Full Text Article] [PubMed:25779031]
5
CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients. Ruixia Huang, Dan Wu, Yuan Yuan, Xiaoran Li, Ruth Holm, Claes G Trope, Jahn M Nesland, Zhenhe Suo. PloS one. 2014 November;9:e112209. [Full Text Article] [PubMed:25380303] [PMC:PMC4224427]
6
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype. Lisanne T Laagland, Frances C Bach, Laura B Creemers, Christine L Le Maitre, Deepani W Poramba-Liyanage, Marianna A Tryfonidou. JOR spine. 2022 September;5:e1219. [Full Text Article] [PubMed:36203869] [PMC:PMC9520765] Related Antibodies: LS-B8284.
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Products
ELISA Kits (23)
Competitive EIA (3)
Custom (4)
Development Kit (1)
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Sandwich CLIA (1)
NT5E / eNT / CD73 (23)
Human (9)
Mouse (2)
Rat (5)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
Product Group
DevKit DuoPlus (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (20)
Antibody Pair and Standard (1)
No (23)
Cell Culture Supernatants (6)
Cell Lysates (3)
Plasma (16)
Serum (16)
Tissue Homogenates (7)
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
NT5E / eNT / CD73 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$632
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NT5E / eNT / CD73 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
NT5E / eNT / CD73 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
NT5E / eNT / CD73 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NT5E / eNT / CD73 ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
NT5E / eNT / CD73 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,229; 1000 Wells/$1,826
NT5E / eNT / CD73 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
0.625 - 40 mIU/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$897
NT5E / eNT / CD73 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
NT5E / eNT / CD73 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
NT5E / eNT / CD73 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).