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NRP1 / Neuropilin 1

neuropilin 1

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Name: neuropilin 1
Synonyms: NRP1, BDCA4, CD304, CD304 antigen, VEGF165 receptor, VEGF165R, Neuropilin 1, Neuropilin-1, Np-1, Npn-1, NRP, NP1, Transmembrane receptor
Target Sequences: NM_003873 NP_003864.4 O14786

Publications (2)

1
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P. Molecular and cellular biology. 2012 32:606-18. [PubMed:22124154] [PMC:PMC3266605] Related Antibodies: LS-C163016.
2
Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1. Julien Rossignol, Zakia Belaid, Guillemette Fouquet, Flavia Guillem, Rachel Rignault, Pierre Milpied, Amédée Renand, Tereza Coman, Maud D'Aveni, Michael Dussiot, Elia Colin, Jonathan Levy, Caroline Carvalho, Nicolas Goudin, Nicolas Cagnard, Francine Côté, Joel Babdor, Kanit Bhukhai, Laura Polivka, Amélie E Bigorgne, Héloise Halse, Aurélien Marabelle, Séverine Mouraud, Yves Lepelletier, Thiago T Maciel, Marie-Thérèse Rubio, Delphine Heron, Caroline Robert, Isabelle Girault, Doris Lebeherec, Jean-. iScience. 2022 June;25:104353. [Full Text Article] [PubMed:35874918] [PMC:PMC9301874] Related Antibodies: LS-C177530.

☰ Filters
Products
Proteins (24)
Over-Expression Lysate (6)
Recombinant (18)
NRP1 / Neuropilin 1 (24)
No (24)
6His, N-terminus (1)
AVI-6His, C-terminus (1)
Fc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (8)
His,C-terminus (1)
His-GST (1)
His-MBP (1)
Myc-DDK (Flag) (8)
Human (13)
Mouse (4)
Rat (4)
293T Cells (3)
E. coli (11)
HEK 293 Cells (7)
Human (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (3)
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E. coli
His
14.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
96.5 kDa
50 µg/$721
NRP1 / Neuropilin 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NRP1 / Neuropilin 1 Protein - Recombinant Human Neuropilin-1/NRP1 (C-Avi-6His) Biotinylated
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Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
72.5 kDa
20 µg/$416; 100 µg/$910
NRP1 / Neuropilin 1 Protein - 12.5% SDS-PAGE of human NRP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
94.16 kDa
10 µg/$479; 25 µg/$670
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
71.3 kDa
50 µg/$721
NRP1 / Neuropilin 1 Protein - Recombinant Neuropilin 1 By SDS-PAGE
Select
E. coli
His
15.0 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
NRP1 / Neuropilin 1 Protein - Recombinant Neuropilin 1 By SDS-PAGE
Select
E. coli
His
20.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
His
14.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
His
18.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
His
18.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
His
14.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
NRP1 / Neuropilin 1 Protein - Recombinant Neuropilin 1 By SDS-PAGE
Select
E. coli
His-GST
41.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
His
21.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
NRP1 / Neuropilin 1 Protein - Recombinant Neuropilin 1 By SDS-PAGE
Select
E. coli
His-MBP
75.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
102.9 kDa
100 µg/$710
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
71.7 kDa
100 µg/$494
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
100 µg/$494
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
102.9 kDa
20 µg/$215
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$150
NRP1 / Neuropilin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
71.7 kDa
20 µg/$150
NRP1 / Neuropilin 1 Protein - Purified recombinant protein NRP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
71.7 kDa
20 µg/$1,107
NRP1 / Neuropilin 1 Protein - Purified recombinant protein NRP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$1,107
NRP1 / Neuropilin 1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
72 kDa
50 µg/$315; 100 µg/$365; 500 µg/$949; 10 µg/$265
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).