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NRP1 / Neuropilin 1
neuropilin 1
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
| Gene Name: | neuropilin 1 |
| Synonyms: | NRP1, BDCA4, CD304, CD304 antigen, VEGF165 receptor, VEGF165R, Neuropilin 1, Neuropilin-1, Np-1, Npn-1, NRP, NP1, Transmembrane receptor |
| Target Sequences: | NM_003873 NP_003864.4 O14786 |
Publications (2)
1
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P. Molecular and cellular biology. 2012 32:606-18.
[PubMed:22124154]
[PMC:PMC3266605]
Related Antibodies: LS-C163016.
2
Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1. Julien Rossignol, Zakia Belaid, Guillemette Fouquet, Flavia Guillem, Rachel Rignault, Pierre Milpied, Amédée Renand, Tereza Coman, Maud D'Aveni, Michael Dussiot, Elia Colin, Jonathan Levy, Caroline Carvalho, Nicolas Goudin, Nicolas Cagnard, Francine Côté, Joel Babdor, Kanit Bhukhai, Laura Polivka, Amélie E Bigorgne, Héloise Halse, Aurélien Marabelle, Séverine Mouraud, Yves Lepelletier, Thiago T Maciel, Marie-Thérèse Rubio, Delphine Heron, Caroline Robert, Isabelle Girault, Doris Lebeherec, Jean-. iScience. 2022 June;25:104353. [Full Text Article]
[PubMed:35874918]
[PMC:PMC9301874]
Related Antibodies: LS-C177530.
☰ Filters
Products
Proteins
(24)
Type
Over-Expression Lysate
(6)
Recombinant
(18)
Target
NRP1 / Neuropilin 1
(24)
Publications
No
(24)
Tag
6His, N-terminus
(1)
AVI-6His, C-terminus
(1)
Fc, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(8)
His,C-terminus
(1)
His-GST
(1)
His-MBP
(1)
Myc-DDK (Flag)
(8)
Species
Human
(13)
Mouse
(4)
Rat
(4)
Source
293T Cells
(3)
E. coli
(11)
HEK 293 Cells
(7)
Human
(1)
Wheat Germ Extract
(2)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(3)
Wheat Germ Extract
GST
94.16 kDa
10 µg/$479; 25 µg/$670
E. coli
His
14.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
71.7 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
102.9 kDa
100 µg/$710
293T Cells
Myc-DDK (Flag)
71.7 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
102.9 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$150
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
72.5 kDa
20 µg/$416; 100 µg/$910
HEK 293 Cells
Myc-DDK (Flag)
71.7 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
100 µg/$494
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
96.5 kDa
50 µg/$721
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
71.3 kDa
50 µg/$721
E. coli
6His, N-terminus
72 kDa
50 µg/$315; 100 µg/$365; 500 µg/$949; 10 µg/$265
E. coli
His
20.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His
15.0 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His
14.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
18.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
18.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
14.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-GST
41.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
21.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-MBP
75.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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