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NRP1 / Neuropilin 1
neuropilin 1
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
| Gene Name: | neuropilin 1 |
| Synonyms: | NRP1, BDCA4, CD304, CD304 antigen, VEGF165 receptor, VEGF165R, Neuropilin 1, Neuropilin-1, Np-1, Npn-1, NRP, NP1, Transmembrane receptor |
| Target Sequences: | NM_003873 NP_003864.4 O14786 |
Publications (2)
1
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P. Molecular and cellular biology. 2012 32:606-18.
[PubMed:22124154]
[PMC:PMC3266605]
Related Antibodies: LS-C163016.
2
Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1. Julien Rossignol, Zakia Belaid, Guillemette Fouquet, Flavia Guillem, Rachel Rignault, Pierre Milpied, Amédée Renand, Tereza Coman, Maud D'Aveni, Michael Dussiot, Elia Colin, Jonathan Levy, Caroline Carvalho, Nicolas Goudin, Nicolas Cagnard, Francine Côté, Joel Babdor, Kanit Bhukhai, Laura Polivka, Amélie E Bigorgne, Héloise Halse, Aurélien Marabelle, Séverine Mouraud, Yves Lepelletier, Thiago T Maciel, Marie-Thérèse Rubio, Delphine Heron, Caroline Robert, Isabelle Girault, Doris Lebeherec, Jean-. iScience. 2022 June;25:104353. [Full Text Article]
[PubMed:35874918]
[PMC:PMC9301874]
Related Antibodies: LS-C177530.
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NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (Asp525) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa476-525) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
NRP1 / Neuropilin 1 Mouse anti-Human Monoclonal (446921) Antibody
Human
Flo
Unconjugated
100 µg/$962
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Microplate
Mouse
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa646-814) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NRP1 / Neuropilin 1 Rabbit anti-Rat Polyclonal (aa813-827) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
100 µg/$386
NRP1 / Neuropilin 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
NRP1 / Neuropilin 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
100 µl/$412
NRP1 / Neuropilin 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$371
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa722-750) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa504-827) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
NRP1 / Neuropilin 1 Rabbit anti-Mouse Polyclonal (aa275-424) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$329; 200 µl/$379; 500 µl/$547; 1 ml/$649; 2 ml/$884; 5 ml/$1,475
NRP1 / Neuropilin 1 Rabbit anti-Human Polyclonal (aa27-143) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$707
Wheat Germ Extract
GST
94.16 kDa
10 µg/$479; 25 µg/$670
E. coli
His
14.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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