NRG3

neuregulin 3

NRG3 is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

NRG3 (3)

Publications

No (3)

Tag

6His-SUMO, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Purification

Purified (1)

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Human NRG3 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-360) - LS-G56432

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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NRG3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128190

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.9 kDa

Price:

100 µg/$494

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Human NRG3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92721

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.9 kDa

Price:

20 µg/$150

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