NRG1 / Heregulin / Neuregulin

neuregulin 1

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

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Products

Proteins (35)

Type

Over-Expression Lysate (14)

Recombinant (21)

Target

NRG1 / Heregulin / Neuregulin (35)

Format

Animal-free (1)

Publications

No (34)

Yes (1)

Tag

6His, N-terminus (1)

GST (1)

His (4)

His-GST, N-terminus (1)

Myc-DDK (Flag) (14)

Species

Human (24)

Mouse (1)

Rat (3)

Source

293T Cells (7)

E. coli (20)

HEK 293 Cells (7)

Wheat Germ Extract (1)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (12)

Biologically Active

Biologically active (11)

Animal-free

Animal-free (1)

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Mouse NRG1 / Heregulin / Neuregulin Protein (Recombinant His-GST, N-terminus) (Ser54-His163) - LS-G14385

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

45.3 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant 6His, N-terminus) (Met1-Lys246) - LS-G39858

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

29kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (aa177-241) - LS-G5837

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.4 kDa

Price:

10 µg/$282; 100 µg/$503; 500 µg/$1,058

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Rat NRG1 / Heregulin / Neuregulin Protein (Recombinant His) (aa328-486) - LS-G14390

Source:

E. coli

Tag:

His

Molecular Weight:

18.9 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) - LS-G5

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.5 kDa

Price:

10 µg/$268; 50 µg/$349

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) - LS-G3634

(4.0) Rating

(1) Publication(s)

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

10 µg/$281; 50 µg/$369

• Unmodified
• Animal-free

• Unmodified
• Animal-free

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (aa122-186) - LS-G5827

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.5 kDa

Price:

10 µg/$282; 100 µg/$503; 500 µg/$1,058

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (aa177-237) - LS-G5829

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.0 kDa

Price:

10 µg/$282; 100 µg/$503; 500 µg/$1,058

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Rat NRG1 / Heregulin / Neuregulin Protein (Recombinant His) (aa264-393) - LS-G14386

Source:

E. coli

Tag:

His

Molecular Weight:

15.9 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Rat NRG1 / Heregulin / Neuregulin Protein (Recombinant His) (aa37-169) - LS-G14389

Source:

E. coli

Tag:

His

Molecular Weight:

16.0 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant His) (aa20-242) - LS-G14380

Source:

E. coli

Tag:

His

Molecular Weight:

26.3 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant GST) (Full Length) - LS-G28820

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.5 kDa

Price:

2 µg/$439

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (Ser177-Glu241) - LS-G39860

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

7.5kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (Thr176-Lys246) - LS-G39859

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.2kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human NRG1 / Heregulin / Neuregulin Protein (Recombinant) (Ser2-Lys246) - LS-G39151

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

26.9kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81412

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.2 kDa

Price:

20 µg/$215

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81404

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

20 µg/$150

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81405

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.3 kDa

Price:

20 µg/$150

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81406

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.2 kDa

Price:

20 µg/$150

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81407

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71 kDa

Price:

20 µg/$215

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81408

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

20 µg/$150

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Human NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81411

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26 kDa

Price:

20 µg/$150

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NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128025

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.2 kDa

Price:

100 µg/$494

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NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128257

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.3 kDa

Price:

100 µg/$494

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NRG1 / Heregulin / Neuregulin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128275

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

100 µg/$494

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