NRF1 / NRF-1

nuclear respiratory factor 1

NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 forms a homodimer and binds DNA as a dimer. NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues. Phosphorylation of NRF1 enhances DNA binding. Multiple splice variants have been identified for this protein.

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Products

ELISA Kits (4)

Type

DNA Binding (1)

Sandwich (3)

Target

NRF1 / NRF-1 (4)

Reactivity

Human (1)

Mouse (2)

Rat (1)

Format

12 x 8-Well Microstrips (1)

96-Well Strip Plate (3)

Publications

No (4)

Sample Type

Cell Lysates (3)

Nuclear Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

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Human NRF1 / NRF-1 (DNA-Binding ELISA) ELISA Kit - LS-F789

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Rat NRF1 / NRF-1 (Sandwich ELISA) ELISA Kit - LS-F7018

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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Mouse NRF1 / NRF-1 (Sandwich ELISA) ELISA Kit - LS-F38500

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse NRF1 / NRF-1 (Sandwich ELISA) ELISA Kit - LS-F25383

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

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