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NRF1 / NRF-1
nuclear respiratory factor 1
NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 forms a homodimer and binds DNA as a dimer. NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues. Phosphorylation of NRF1 enhances DNA binding. Multiple splice variants have been identified for this protein.
| Gene Name: | nuclear respiratory factor 1 |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | NRF1, EWG, NRF-1, Nuclear respiratory factor 1, ALPHA-PAL |
| Target Sequences: | NM_005011 NP_005002.3 Q16656 |
Publications (1)
1
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment. Zou P, Liu L, Zheng LD, Payne KK, Manjili MH, Idowu MO, Zhang J, Schmelz EM, Cheng Z. Oxidative medicine and cellular longevity. 2016 2016:4085727. (WB; Human)
[Full Text Article]
[PubMed:27746856]
[PMC:PMC5056295]
Related Antibodies: LS-B43.
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(4)
NRF1 / NRF-1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$535
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa360-409) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa360-409) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa360-409) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa360-409) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa429-478) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa429-478) (Biotin) Antibody
Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa429-478) (FITC) Antibody
Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa272-288) Antibody
Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Guinea pig, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa1-300) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
DNA Binding
12 x 8-Well Microstrips
Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$694
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
NRF1 / NRF-1 Mouse anti-Human Monoclonal (2F9) Antibody
Human
ELISA, RNAi, WB
Unconjugated
50 µg/$423
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
NRF1 / NRF-1 Rabbit anti-Human Polyclonal (aa1-300) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
NRF1 / NRF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NRF1 / NRF-1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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