NRAS / N-ras

neuroblastoma RAS viral (v-ras) oncogene homolog

The N-ras oncogene is a member of the RAS gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The order of nearby genes is as follows: cen--CD2--NGFB--NRAS--tel. The mammalian ras gene family consists of the harvey and kirsten ras genes (c-Hras1 and c-Kras2), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to transform cultured cells and are implicated in a variety of human tumors. The N-ras gene specifies two main transcripts of 2Kb and 4.3Kb. The difference between the two transcripts is a simple extension through the termination site of the 2Kb transcript. The N-ras gene consists of seven exons (-I, I, II, III, IV, V, VI). The smaller 2Kb transcript contains the VIa exon, and the larger 4.3Kb transcript contains the VIb exon which is just a longer form of the VIa exon. Both transcripts encode identical proteins as they differ only the 3' untranslated region. The sequence of the shorter 2Kb transcript is presented here. The 4.3 Kb transcript sequence is not available.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

NRAS / N-ras (8)

Publications

No (8)

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GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Myc-DDK (Flag), C-terminus (1)

Species

Human (8)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

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Purified (1)

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Human NRAS / N-ras Protein (Recombinant) - LS-G714

Source:

E. coli

Tag:

None

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human NRAS / N-ras Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99784

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21 kDa

Price:

100 µg/$494

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Human NRAS / N-ras Protein (Recombinant GST) (Full Length) - LS-G29544

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NRAS / N-ras Protein (Recombinant GST, N-terminus) (aa90-189) - LS-G59444

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NRAS / N-ras Protein (Recombinant His) (Met1-Cys186) - LS-G98884

Source:

E. coli

Tag:

His

Molecular Weight:

23 kDa

Price:

100 µg/$843

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Human NRAS / N-ras Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79293

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21 kDa

Price:

20 µg/$150

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Human NRAS / N-ras Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67180

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21 kDa

Price:

20 µg/$1,107

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Human NRAS / N-ras Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142300

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

21 kDa

Price:

20 µg/$1,107

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