NR5A2 / LRH-1

nuclear receptor subfamily 5, group A, member 2

Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as 'human B1-binding factor' (HB1F), 'CYP7A promoter-binding factor' (CPF), and 'liver receptor homolog 1' (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain).

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NR5A2 / LRH-1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NR5A2 / LRH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80645

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.3 kDa

Price:

20 µg/$215

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Human NR5A2 / LRH-1 Protein (Recombinant His-T7) (aa300-541) - LS-G25399

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Rat NR5A2 / LRH-1 Protein (Recombinant His-T7) (aa1-205) - LS-G25400

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human NR5A2 / LRH-1 Protein (Recombinant GST, N-terminus) (aa431-540) - LS-G58613

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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NR5A2 / LRH-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100139

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.3 kDa

Price:

100 µg/$710

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Human NR5A2 / LRH-1 Protein (Recombinant GST) (Full Length) - LS-G28518

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.9 kDa

Price:

10 µg/$479; 25 µg/$670

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