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NR5A1 / SF1
nuclear receptor subfamily 5, group A, member 1
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
| Gene Name: | nuclear receptor subfamily 5, group A, member 1 |
| Family/Subfamily: | NHR , NR5 Fushi tarazu-like |
| Synonyms: | NR5A1, AD4BP, Adrenal 4 binding protein, Adrenal 4-binding protein, ELP, Steroidogenic factor-1, SRXY3, Steroidogenic factor 1, Nuclear receptor AdBP4, Nuclear receptor elp, POF7, SF-1, SPGF8, Steroid hormone receptor Ad4BP, STF-1, FTZ1, FTZF1, Fushi tarazu factor homolog 1 |
| Target Sequences: | U76388 NP_004950.2 Q13285 |
Publications (1)
1
Rapid Differentiation of Human Embryonic Stem Cells into Testosterone-Producing Leydig Cell-Like Cells In vitro. Eun-Young Shin, Seah Park, Won Yun Choi, Dong Ryul Lee. Tissue engineering and regenerative medicine. 2021 Aug;;18:651-662. [Full Text Article]
[PubMed:34165777]
[PMC:PMC8325741]
Related Antibodies: LS-C162999.
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Fast Shipping
NR5A1 / SF1 Rabbit anti-Human Polyclonal (Internal) Antibody
Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Cancer Pathology
Cancer
Fast Shipping
NR5A1 / SF1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
NR5A1 / SF1 Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Human
IHC-P
Unconjugated
50 µg/$440
Fast Shipping
NR5A1 / SF1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC-P
Unconjugated
50 µg/$440
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NR5A1 / SF1 Mouse anti-Human Monoclonal (aa1-262) (OTI1B4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NR5A1 / SF1 Mouse anti-Human Monoclonal (aa1-262) (Carrier-free) (OTI1B4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa64-93) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa169-218) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR5A1 / SF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
Wheat Germ Extract
GST, N-terminus
78 kDa
10 µg/$479; 25 µg/$670
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa172-221) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa172-221) (HRP) Antibody
Rabbit, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa172-221) (Biotin) Antibody
Rabbit, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa172-221) (FITC) Antibody
Rabbit, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR5A1 / SF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
NR5A1 / SF1 Mouse anti-Human Monoclonal (aa1-262) (OTI10E2) Antibody
Human
IHC
Unconjugated
100 µl/$434
NR5A1 / SF1 Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Rabbit, Dog, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR5A1 / SF1 Rabbit anti-Human Polyclonal (aa143-192) (FITC) Antibody
Rabbit, Dog, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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