NR4A2 / NURR1

nuclear receptor subfamily 4, group A, member 2

Nuclear receptor Nurr1, a NR4 Nerve Growth Factor-Like Receptor, has been shown to affect the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic dopaminergic (DA) neurons. It has been shown that the receptor tyrosine kinase Ret1 is regulated by Nurr1 in midbrain dopamine neurons. Nurr1 binds to target DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nurr1-null mice fail to generate midbrain neurons with a dopaminergic phenotype, and midbrain dopamine precursor cells degenerate during brain development. Nurr1-null mice have similar brain structure as patients with Parkinson's disease. Mutation in the Nurr1 sequence has been documented in patients with schizophrenia and manic-depression, and more recently, in Parkinson's disease (Le et al. 2002). Nurr2, an alternatively spliced and truncated protein isoform of Nurr1, has been isolated from mouse. Nurr2 has a novel cryptic exon located upstream in the Nurr1 promoter region and is generated by alternative splicing at exons 1, 2, and 6. The existence of Nurr2 mRNA has also been reported in human and rat. Recent findings indicate that Nurr1 may play a role in mediating some of the anti-proliferative effects of 6-mercaptopurine and potentially implicate Nurr1 as a molecular target for treatment of leukemias ( Ordentlich et al. 2003).

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Target

NR4A2 / NURR1 (45)

Reactivity

Human (37)

Mouse (15)

Rat (13)

Bat (9)

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rabbit (34)

mouse (3)

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IHCPlus (1)

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monoclonal mc (3)

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Unconjugated (16)

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aa1-335 (8)

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N-Terminus (4)

aa503-552 (4)

aa13-42 (1)

aa164-197 (1)

aa344-530 (1)

aa380-412 (1)

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E. coli (1)

HEK 293 Cells (1)

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Yeast (1)

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Purified (1)

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NR4A2 / NURR1 Antibody (aa13-42) LS-C99204

(4.1) Rating

(2) Publication(s)

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (aa13-42) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PathPlus™ NR4A2 / NURR1 Antibody (C-Terminus) LS-B13152

Neuroscience

(5.0) Rating

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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NR4A2 / NURR1 Antibody (C-Terminus, HRP) LS-C428445

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Insect, Drosophila, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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NR4A2 / NURR1 Antibody (C-Terminus, Biotin) LS-C428444

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Insect, Drosophila, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NR4A2 / NURR1 Antibody (C-Terminus, FITC) LS-C428443

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Insect, Drosophila, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

NR4A2 / NURR1 Antibody (aa344-530) LS-C311816

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (aa344-530) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$450

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Human NR4A2 / NURR1 Protein (Recombinant His, N-Terminal) (aa1-335) - LS-G25398

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

40.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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NR4A2 / NURR1 Antibody (aa503-552) LS-C110316

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (aa503-552) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

NR4A2 / NURR1 Antibody (N-Terminus) LS-B4582

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

NR4A2 / NURR1 Antibody (N-Terminus, HRP) LS-C437481

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

NR4A2 / NURR1 Antibody (N-Terminus, Biotin) LS-C437479

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NR4A2 / NURR1 Antibody (N-Terminus, FITC) LS-C437480

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human NR4A2 / NURR1 (Sandwich ELISA) ELISA Kit - LS-F49626

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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NR4A2 / NURR1 Antibody LS-C73801

Antibody:

NR4A2 / NURR1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$558

Select

Human NR4A2 / NURR1 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G136596

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

68.6 kDa

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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NR4A2 / NURR1 Antibody LS-C16919

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$832

Select

NR4A2 / NURR1 Antibody (HRP) LS-C548410

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,054

Select

NR4A2 / NURR1 Antibody (Biotin) LS-C528308

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,054

Select

NR4A2 / NURR1 Antibody (FITC) LS-C538266

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,054

Select

NR4A2 / NURR1 Antibody (APC) LS-C518434

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

100 µl/$1,054

Select

NR4A2 / NURR1 Antibody (PE) LS-C656431

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Rodent, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$1,054

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

Select

Human NR4A2 / NURR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66010

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.4 kDa

Price:

20 µg/$1,107

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NR4A2 / NURR1 Antibody LS-C816839

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

NR4A2 / NURR1 Antibody LS-C752548

Antibody:

NR4A2 / NURR1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$351

Select

NR4A2 / NURR1 Antibody (clone 2C12) LS-C139061

Antibody:

NR4A2 / NURR1 Mouse anti-Human Monoclonal (2C12) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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