NR3C1/Glucocorticoid Receptor

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

The glucocorticoid receptor (GR), a NR3 Steroid Receptor, mediates the physiological activities of glucocorticoids that modulate development, homeostasis, stress, inflammatory, and immunologic responses. GR has been shown to mediate negative-feedback signals of elevated glucocorticoid levels; impaired GR signaling is a key mechanism in the pathogenesis of stress-related psychiatric disorders such as depression and anxiety. Over ten kindreds and sporadic cases of glucocorticoid resistance have been reported; several of these result from mutations in the GR ligand-binding domain. In addition, tissue-specific changes in glucocorticoid sensitivity have been associated with diseases such as rheumatoid arthritis, systemic lupus erythematosus, a type of bronchial asthma, and possibly AIDS. The human GR has three alternatively spliced isoforms: alpha, beta, and gamma. The alpha and beta isoforms are identical through amino acid 727 but then diverge, with GR alpha containing an additional 50 amino acids and GR beta containing an additional, nonhomologous 15 amino acids. GR alpha is activated by glucocorticoid hormones and can bind to the glucocorticoid response element (GRE). GR beta does not bind glucocorticoid hormones and is transcriptionally inactive; however, GR beta can bind GRE and act as an inhibitor of GR alpha. GR gamma, which contains one additional amino acid (arginine) in the DNA-binding domain based on cDNA translation, has been described by Rivers et al. 1999.

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Products

ELISA Kits (23)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

DNA Binding (1)

DNA Binding Phosphorylation (1)

Sandwich (14)

Sandwich CLIA (2)

Target

NR3C1/Glucocorticoid Receptor (23)

Reactivity

Human (9)

Mouse (9)

Rat (10)

Chicken (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (4)

96-Well Microplate (4)

96-Well Strip Plate (15)

Publications

No (23)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (7)

Nuclear Lysates (2)

Plasma (8)

Serum (8)

Tissue Homogenates (8)

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Human NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F8204

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F39288

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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Mouse/Human/Rat Phospho-NR3C1/Glucocorticoid Receptor (Ser211) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F879

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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Rat NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F4309

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

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Mouse NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F8686

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$782

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Mouse/Human/Rat NR3C1/Glucocorticoid Receptor (Cell-Based ELISA) ELISA Kit - LS-F2024

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-NR3C1/Glucocorticoid Receptor (Ser211) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1087

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F11518

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Pig NR3C1/Glucocorticoid Receptor (Custom ELISA) ELISA Kit - LS-F18109

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Rat NR3C1/Glucocorticoid Receptor (Custom ELISA) ELISA Kit - LS-F18108

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F33000

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse NR3C1/Glucocorticoid Receptor (CLIA) ELISA Kit - LS-F30726

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

3.125 - 200 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Rat NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F36915

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NR3C1/Glucocorticoid Receptor (CLIA) ELISA Kit - LS-F29867

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Chicken NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F44417

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F44420

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F44419

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F44421

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rat NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F53814

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$822

Select

Rat NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F21538

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human NR3C1/Glucocorticoid Receptor (Sandwich ELISA) ELISA Kit - LS-F4311

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

Select

Mouse/Human/Rat NR3C1/Glucocorticoid Receptor (DNA-Binding ELISA) ELISA Kit - LS-F880

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

Select

Mouse/Human/Rat Phospho-NR3C1/Glucocorticoid Receptor (Ser226) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1136

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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