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NR2C1

nuclear receptor subfamily 2, group C, member 1

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Gene Name: nuclear receptor subfamily 2, group C, member 1
Family/Subfamily: NHR , NR2 Hepatocyte NF4-like
Synonyms: NR2C1, Orphan nuclear receptor TR2, Testicular orphan receptor-2, TR2, TR2 nuclear hormone receptor, TR2-11, Testicular receptor 2
Target Sequences: NM_003297 NP_003288.2 P13056

Publications (1)

1
Testicular receptor 2, Nr2c1, is associated with stem cells in the developing olfactory epithelium and other cranial sensory and skeletal structures. Baker JL, Wood B, Karpinski BA, LaMantia AS, Maynard TM. Gene expression patterns : GEP. 2016 January;20:71-79. [Full Text Article] [PubMed:26712358] [PMC:PMC4858322] Related Antibodies: LS-C338722.

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
NR2C1 (8)
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GST (1)
GST, N-terminus (1)
His-T7, N-terminus (2)
Myc-DDK (Flag) (4)
Human (5)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (3)
NR2C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.8 kDa
100 µg/$710
NR2C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51 kDa
100 µg/$494
NR2C1 Protein - Recombinant Testicular Receptor 2 (TR2) by SDS-PAGE
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E. coli
His-T7, N-terminus
39.3kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
NR2C1 Protein - Recombinant Testicular Receptor 2 (TR2) by SDS-PAGE
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E. coli
His-T7, N-terminus
37.8kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
NR2C1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NR2C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.8 kDa
20 µg/$215
NR2C1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51 kDa
20 µg/$150
NR2C1 Protein - 12.5% SDS-PAGE of human NR2C1 stained with Coomassie Blue
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Wheat Germ Extract
GST
77.6 kDa
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).