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NR1H3 / LXR Alpha
nuclear receptor subfamily 1, group H, member 3
Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.
| Gene Name: | nuclear receptor subfamily 1, group H, member 3 |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | NR1H3, Liver X receptor alpha, LXRA, LXR-a, Oxysterols receptor LXR-alpha, LXR alpha, Lxralpha, RLD-1 |
| Target Sequences: | NM_005693 NP_005684.2 Q13133 |
Publications (6)
1
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. Thomas AC, Eijgelaar WJ, Daemen MJ, Newby AC. PloS one. 2015 10:e0128163. (IHC; Mouse)
[Full Text Article]
[PubMed:26197235]
[PMC:PMC4510387]
Related Antibodies: LS-B3526.
2
Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH. Physiological reports. 2016 4: (WB; Human)
[Full Text Article]
[PubMed:27401460]
[PMC:PMC4945843]
Related Antibodies: LS-C172075.
3
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1. Zinkhan EK, Yu B, Schlegel A. Frontiers in physiology. 2018 May;9:645. (Human)
[Full Text Article]
[PubMed:29896121]
[PMC:PMC5987111]
Related Antibodies: LS-C172075.
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NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
NR1H3 / LXR Alpha Mouse anti-Human Monoclonal (aa164-447) Antibody
Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$941
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
WB
Unconjugated
100 µg/$341
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (C-Terminus) (Magnetic beads) Antibody
Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
NR1H3 / LXR Alpha Rabbit anti-Cow Polyclonal (aa95-434) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$328; 200 µl/$379; 500 µl/$547; 1 ml/$648; 2 ml/$883; 5 ml/$1,471
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NR1H3 / LXR Alpha Mouse anti-Human Monoclonal (3E9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
NR1H3 / LXR Alpha Goat anti-Human Polyclonal (aa384-397) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Goat, Dog, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa375-398) Antibody
Mouse, Rat, Hamster, Human
WB
Unconjugated
100 µg/$575
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
NR1H3 / LXR Alpha Mouse anti-Human Monoclonal (aa69-329) (OTI1A5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
NR1H3 / LXR Alpha Mouse anti-Human Monoclonal (aa69-329) (Carrier-free) (OTI1A5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1H3 / LXR Alpha Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$351
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal (aa226-253) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
NR1H3 / LXR Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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