NR1D2

nuclear receptor subfamily 1, group D, member 2

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NR1D2 (5)

Publications

No (5)

Tag

GST (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Purified (1)

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Human NR1D2 Protein (Recombinant GST) (Full Length) - LS-G31882

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.21 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NR1D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80764

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.5 kDa

Price:

20 µg/$150

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Human NR1D2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67805

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.5 kDa

Price:

20 µg/$1,107

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NR1D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116148

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.5 kDa

Price:

100 µg/$494

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Rat NR1D2 Protein (Recombinant His-GST) (aa249-578) - LS-G25395

Source:

E. coli

Tag:

His-GST

Molecular Weight:

67.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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