NR0B2

nuclear receptor subfamily 0, group B, member 2

SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway.

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Antibodies (65)

Proteins (6)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (65)

Recombinant (4)

Sandwich (1)

Target

NR0B2 (72)

Reactivity

Human (57)

Mouse (9)

Rat (12)

Bovine (3)

Chimpanzee (9)

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IHC (22)

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rabbit (52)

mouse (13)

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IHCPlus (1)

PathPlus Cancer (2)

Isotype

IgG (31)

IgG1 (4)

IgG2a (6)

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IgG2b (2)

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monoclonal mc (13)

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1A11 (1)

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aa1-257 (8)

aa1-260 (8)

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aa146-195 (4)

aa182-231 (4)

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aa64-257 (1)

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No (70)

Yes (2)

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Tag

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Myc-DDK (Flag) (2)

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Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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PathPlus™ NR0B2 Antibody (Ligand-binding Domain) LS-A5411

Cancer

Fast Shipping

(5.0) Rating

(3) Publication(s)

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody

Reactivity:

Rabbit, Mouse, Hamster, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$395

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NR0B2 Antibody (aa110-159) LS-B3560

(4.0) Rating

(1) Publication(s)

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa110-159) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$375

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NR0B2 Antibody (aa110-159, HRP) LS-C447436

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa110-159) (HRP) Antibody

Reactivity:

Rabbit, Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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NR0B2 Antibody (aa110-159, Biotin) LS-C447871

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa110-159) (Biotin) Antibody

Reactivity:

Rabbit, Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NR0B2 Antibody (aa110-159, FITC) LS-C447872

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa110-159) (FITC) Antibody

Reactivity:

Rabbit, Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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NR0B2 Antibody LS-C331719

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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NR0B2 Antibody (aa56-83) LS-C162982

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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NR0B2 Antibody (aa56-83) LS-C323430

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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NR0B2 Antibody (aa56-83, Biotin) LS-C238163

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

NR0B2 Antibody (aa56-83, FITC) LS-C238164

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

NR0B2 Antibody (aa56-83, Azide-free, HRP) LS-C248950

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

NR0B2 Antibody (aa56-83, APC) LS-C238162

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

NR0B2 Antibody (aa56-83, PE) LS-C238168

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa56-83) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

NR0B2 Antibody LS-C809575

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$282; 200 µl/$350

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NR0B2 Antibody (aa64-257) LS-C186332

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (aa64-257) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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PathPlus™ NR0B2 Antibody (C-Terminus) LS-A5395

Cancer

Fast Shipping

(5.0) Rating

Antibody:

NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$395

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NR0B2 Antibody (clone 1A11) LS-C198561

Antibody:

NR0B2 Mouse anti-Human Monoclonal (1A11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$335

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NR0B2 Antibody (clone OTI7B5, Carrier-free) LS-C790885

Antibody:

NR0B2 Mouse anti-Human Monoclonal (Carrier-free) (OTI7B5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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NR0B2 Antibody (clone OTI8E5, Carrier-free) LS-C790897

Antibody:

NR0B2 Mouse anti-Human Monoclonal (Carrier-free) (OTI8E5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

Select

NR0B2 Antibody (clone OTI5F10, Carrier-free) LS-C790886

Antibody:

NR0B2 Mouse anti-Human Monoclonal (Carrier-free) (OTI5F10) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

Select

NR0B2 Antibody LS-C835011

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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NR0B2 Antibody LS-C341357

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

NR0B2 Antibody LS-C831743

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

NR0B2 Antibody LS-C781471

Antibody:

NR0B2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

Select

NR0B2 Antibody (clone OTI1A2) LS-C793940

Antibody:

NR0B2 Mouse anti-Human Monoclonal (OTI1A2) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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