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NR0B1 / DAX1
nuclear receptor subfamily 0, group B, member 1
DAX-1 (DSS-AHC critical region on the X chromosome, gene 1) is an orphan NRO Knirps-Like nuclear receptor that is involved in adrenal gland and gonad development. DAX-1 has been shown to negatively regulate transcription of the nuclear receptor steroidogenic factor 1 (SF-1). DAX-1 is also involved in the development and differentiation of anterior pituitary cells and in steroidogenesis. In the nucleus, DAX-1 binds to a retinoic acid-responsive element (RARE) and acts as a dominant-negative regulator of retinoic acid receptor-mediated transcription. DAX-1 gene transcription is regulated by Ad4BP/SF-1 (NR5A1) and is suppressed by androgens and the androgen receptor (AR/NR3C4); AR down-regulated DAX-1 gene transcription is mediated by Ad4BP/SF-1 in the presence of the ligand. Recently it has been shown that DAX-1 is required for testis development (Meeks et al. 2003). Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Recently two isoforms of DAX-1 has been identified.
| Gene Name: | nuclear receptor subfamily 0, group B, member 1 |
| Family/Subfamily: | NHR , NR0 Knirps-like |
| Synonyms: | NR0B1, AHX, AHC, AHCH, DAX1, DSS, DAX 1, DAX-1, Adrenal hypoplasia congenita, Dosage-sensitive sex reversal, GTD, HHG, Nuclear hormone receptor, NROB1, Nuclear receptor DAX-1, SRXY2, Nuclear receptor DAX1, Dax-1 receptor |
| Target Sequences: | NM_000475 NP_000466.2 P51843 |
Publications (1)
1
Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin. Stefan Bornstein, Igor Shapiro, Maria Malyukov, Richard Züllig, Edlira Luca, Evgeny Gelfgat, Felix Beuschlein, Svenja Nölting, Alfredo Berruti, Sandra Sigala, Mirko Peitzsch, Charlotte Steenblock, Barbara Ludwig, Patrick Kugelmeier, Constanze Hantel. Cell death & disease. 2022 July;13:648. [Full Text Article]
[PubMed:35879289]
[PMC:PMC9314441]
Related Antibodies: LS-B3480.
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NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa359-408) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Fast Shipping
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Fast Shipping
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa151-200) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
NR0B1 / DAX1 Goat anti-Human Polyclonal (aa202-214) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa96-406) Antibody
Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$450
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (aa304-333) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
NR0B1 / DAX1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
![NR0B1 / DAX1 Antibody - Immunofluorescence of monoclonal antibody to NR0B1 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/nr0b1-dax1-antibody-clone-2f12-ls-c196629/143819_4943896.jpg)
NR0B1 / DAX1 Mouse anti-Human Monoclonal (2F12) Antibody
Human
ELISA, IF
Unconjugated
100 µg/$423
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR0B1 / DAX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
NR0B1 / DAX1 Mouse anti-Human Monoclonal (aa161-430) (OTI5F5) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
NR0B1 / DAX1 Mouse anti-Human Monoclonal (aa161-430) (Carrier-free) (OTI5F5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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