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NQO1
NAD(P)H dehydrogenase, quinone 1
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Gene Name: | NAD(P)H dehydrogenase, quinone 1 |
| Synonyms: | NQO1, Azoreductase, DHQU, DT-diaphorase, Dioxin-inducible 1, DIA4, Diaphorase-4, NAD(P)H:quinone oxireductase, Phylloquinone reductase, QR1, Menadione reductase, NMOR1, NMORI, DTD, Quinone reductase 1 |
| Target Sequences: | NM_000903 NP_000894.1 P15559 |
Publications (16)
1
Immortalisation of a human diploid fibroblast cell strain: a DT-diaphorase paradox. Kuehl BL, Brezden CB, Traver RD, Siegel D, Ross D, Renzing J, Rauth AM. The British journal of cancer. Supplement. 1996 27:S19-22. (WB; Human)
[PubMed:8763839]
[PMC:PMC2150025]
2
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Siegel D, Ross D. Free radical biology & medicine. 2000 29:246-53.
[PubMed:11035253]
3
Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1. Siegel D, Anwar A, Winski SL, Kepa JK, Zolman KL, Ross D. Molecular pharmacology. 2001 59:263-8. (WB, IP; Human)
[PubMed:11160862]
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NQO1 Goat anti-Human Polyclonal (aa263-274) Antibody
Rabbit, Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$811
NQO1 Mouse anti-Human Monoclonal (A180) Antibody
Dog, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
NQO1 Mouse anti-Human Monoclonal (Biotin) (A180) Antibody
Mouse, Dog, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
NQO1 Mouse anti-Human Monoclonal (DY650) (A180) Antibody
Dog, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
NQO1 Mouse anti-Human Monoclonal (DY488) (A180) Antibody
Dog, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
NQO1 Mouse anti-Human Monoclonal (DY550) (A180) Antibody
Dog, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
NQO1 Mouse anti-Human Monoclonal (AI80) Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$485
NQO1 Goat anti-Human Polyclonal (aa134-146) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Rat
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
NQO1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NQO1 Mouse anti-Human Monoclonal (4D12) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
NQO1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
![NQO1 Antibody - Immunofluorescence of monoclonal antibody to NQO1 on HepG2 cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/nqo1-antibody-clone-1e3-a6-ls-c197049/144542_4936988.jpg)
NQO1 Mouse anti-Human Monoclonal (1E3-A6) Antibody
Human
ELISA, IF, IP, RNAi, WB
Unconjugated
100 µg/$423
NQO1 Rabbit anti-Human Polyclonal (aa213-274) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
NQO1 Rabbit anti-Human Monoclonal (Preservative Free) (002) Antibody
Human
WB
Unconjugated, Preservative Free
100 µl/$412
NQO1 Mouse anti-Human Monoclonal Antibody
Rat, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$649
NQO1 Mouse anti-Human Monoclonal (4D12) Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
100 µl/$541
NQO1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
NQO1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NQO1 Rabbit anti-Human Polyclonal (aa118-144) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
NQO1 Mouse anti-Human Monoclonal Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$572
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$848
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