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NPSR1 / NPSR / GPR154 is a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
Gene Name: | neuropeptide S receptor 1 |
Family/Subfamily: | GPCR , Vasopressin/oxytocin |
Synonyms: | NPSR1, ASRT2, G protein-coupled receptor 154, G-protein coupled receptor 154, GPR154, Neuropeptide S receptor 1, NPSR, PGR14, GPRA, Neuropeptide S receptor, VRR1 |
Target Sequences: | NM_207172 NP_997055.1 Q6W5P4 |
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