Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Gene Name: | nephrosis 1, congenital, Finnish type (nephrin) |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | NPHS1, Nephrin, NPHN, CNF |
Target Sequences: | NM_004646 NP_004637.1 O60500 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.