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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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NPHS1 / Nephrin
nephrosis 1, congenital, Finnish type (nephrin)
NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis. O'Sullivan KM, Ford SL, Longano A, Kitching AR, Holdsworth SR. American journal of physiology. Renal physiology. 2018 November;315:F1283-F1294. [Full Text Article]
[PubMed:29923769]
[PMC:PMC6293285]
2
Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Kentaro Terai, Denan Jin, Kenji Watase, Akihisa Imagawa, Shinji Takai. International journal of molecular sciences. 2020 October;21: [Full Text Article]
[PubMed:33050674]
[PMC:PMC7589797]
Related Antibodies: LS-B1382.
3
Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats. K Salaga-Zaleska, P Pikul, E Kreft, S Herman, G Chyla, K Dabkowski, A Kuchta, M Lenartowicz, M Jankowski. Biomedicine & pharmacotherapy = Biomdecine & pharmacothrapie. 2021 July;139:111683. [Full Text Article]
[PubMed:34243631]
4
Urinary Nephrin as a Biomarker of Glomerular Maturation and Injury Is Associated with Acute Kidney Injury and Mortality in Critically Ill Neonates. Jiao Chen, Gen Li, Sanfeng Wang, Xiaohan Hu, Yunqing Sun, Xiaomei Dai, Zhenjiang Bai, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li. Neonatology. 2019 April;116:58-66. [Full Text Article]
[PubMed:30982033]
5
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. Nature communications. 2019 August;10:3656. [Full Text Article]
[PubMed:31409793]
[PMC:PMC6692336]
Related Antibodies: LS-C370063.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).