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NPC1L1

NPC1-like 1

NPC1L1 is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name:	NPC1-like 1
Family/Subfamily:	Transporter , not assigned-Transporter
Synonyms:	NPC1L1, Niemann-Pick C1-like protein 1, NPC11L1, NPC1-like 1
Target Sequences:	NM_013389 NP_037521.2 Q9UHC9

Publications (13)

CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. Nassir F, Wilson B, Han X, Gross RW, Abumrad NA. The Journal of biological chemistry. 2007 282:19493-501. (WB; Mouse) [PubMed:17507371]

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL. The Journal of biological chemistry. 2008 283:1052-63. (WB; Human) [PubMed:17989073]

Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake. Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E. Journal of lipid research. 2008 49:961-72. (WB; Human) [PubMed:18235139]

Niemann-Pick C1 functions in regulating lysosomal amine content. Kaufmann AM, Krise JP. The Journal of biological chemistry. 2008 283:24584-93. [PubMed:18591242] [PMC:PMC2528997]

Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. Liu W, Mani S, Davis NR, Sarrafzadegan N, Kavathas PB, Mani A. Circulation research. 2008 103:1280-8. (IP; Mouse) [PubMed:18948618] [PMC:PMC3426315]

Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, Naples M, Baker C, Magomedova L, Tam J, Adeli K, Cummins CL, Connelly PW, Ng DS. The Journal of biological chemistry. 2012 287:20755-68. (WB; Mouse) [PubMed:22500017] [PMC:PMC3370258]

Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins. Duangjai A, Ingkaninan K, Praputbut S, Limpeanchob N. Journal of natural medicines. 2013 67:303-10. (WB; Human) [PubMed:22736065]

Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content. Schmitz M, Signore SC, Zerr I, Althaus HH. Journal of molecular neuroscience : MN. 2013 49:457-69. (ICC, WB; Pig) [PubMed:22740150] [PMC:PMC3566395]

Reduction in cholesterol absorption in Caco-2 cells through the down-regulation of Niemann-Pick C1-like 1 by the putative probiotic strains Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74 from fermented foods. Yoon HS, Ju JH, Kim HN, Park HJ, Ji Y, Lee JE, Shin HK, Do MS, Holzapfel W. International journal of food sciences and nutrition. 2013 64:44-52. (WB; Human) [PubMed:22816655]

Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]

D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation. Malhotra P, Boddy CS, Soni V, Saksena S, Dudeja PK, Gill RK, Alrefai WA. American journal of physiology. Gastrointestinal and liver physiology. 2013 304:G203-10. (WB; Human) [PubMed:23139223] [PMC:PMC3543648]

Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease. Young-Chae Kim, Ming Qi, Xingchen Dong, Sunmi Seok, Hao Sun, Byron Kemper, Ting Fu, Jongsook Kim Kemper. The Journal of biological chemistry. 2023 August;299:104946. [Full Text Article] [PubMed:37348559] [PMC:PMC10394163] Related Antibodies: LS-B506.

Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels. Xie P, Zhu H, Jia L, Ma Y, Tang W, Wang Y, Xue B, Shi H, Yu L. Atherosclerosis. Dec;237:609-17. [Full Text Article] [PubMed:25463095] [PMC:PMC4262594] Related Antibodies: LS-B88.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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