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NOX4

NADPH oxidase 4

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

Gene Name:	NADPH oxidase 4
Synonyms:	NOX4, Kidney oxidase-1, KOX, RENOX, KOX-1, NADPH oxidase 4, Renal NAD(P)H-oxidase
Target Sequences:	NM_016931 NP_058627.1 Q9NPH5

Publications (14)

Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice. Kim J, Park JW, Park KM. American journal of physiology. Renal physiology. 2009 296:F1202-11. (WB; Mouse) [PubMed:19193722]

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE. Diabetes. 2009 58:1201-11. (WB; Mouse) [PubMed:19208908] [PMC:PMC2671039]

Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Kodera R, Shikata K, Kataoka HU, Takatsuka T, Miyamoto S, Sasaki M, Kajitani N, Nishishita S, Sarai K, Hirota D, Sato C, Ogawa D, Makino H. Diabetologia. 2011 54:965-78. (ICC, IHC; Rat) [PubMed:21253697]

(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism. Clavreul N, Sansilvestri-Morel P, Magard D, Verbeuren TJ, Rupin A. American journal of physiology. Renal physiology. 2011 300:F1310-8. (WB; Human) [PubMed:21411480]

Cognitive impairment in humanized APPPS1 mice is linked to A(1-42) and NOX activation. Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN. Neurobiology of disease. 2011 44:317-26. [PubMed:21798347] [PMC:PMC3185143]

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Weyemi U, Lagente-Chevallier O, Boufraqech M, Prenois F, Courtin F, Caillou B, Talbot M, Dardalhon M, Al Ghuzlan A, Bidart JM, Schlumberger M, Dupuy C. Oncogene. 2012 31:1117-29. [PubMed:21841825] [PMC:PMC3307059]

Deletion of angiotensin II type 1 receptor gene or scavenge of superoxide prevents chronic alcohol-induced aortic damage and remodelling. Bai Y, Tan Y, Wang B, Miao X, Chen Q, Zheng Y, Cai L. Journal of cellular and molecular medicine. 2012 16:2530-8. (IHC; Mouse) [PubMed:22435601]

Deletion of angiotensin II type 1 receptor gene attenuates chronic alcohol-induced retinal ganglion cell death with preservation of VEGF expression. Miao X, Lv H, Wang B, Chen Q, Miao L, Su G, Tan Y. Current eye research. 2013 38:185-93. (IHC; Mouse) [PubMed:22954336]

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Shao C, Liu Y, Ruan H, Li Y, Wang H, Kohl F, Goropashnaya AV, Fedorov VB, Zeng R, Barnes BM, Yan J. Thorax. 2013 [PubMed:23299965]

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin. Radwa Nasser Muhammad, Nada Sallam, Hanan Salah El-Abhar. Scientific reports. 2020 September;10:14693. [Full Text Article] [PubMed:32895407] [PMC:PMC7477553]

Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma. Dharam Kaushik, Keith A Ashcraft, Hanzhang Wang, Karthigayan Shanmugasundaram, Pankil K Shah, Gabriela Gonzalez, Alia Nazarullah, Cooper B Tye, Michael A Liss, Deepak K Pruthi, Ahmed M Mansour, Wasim Chowdhury, Dean Bacich, Hao Zhang, Amanda L Watson, Karen Block, Denise O'Keefe, Ronald Rodriguez. Translational research : the journal of laboratory and clinical medicine. 2020 Sep;;223:44575. [Full Text Article] [PubMed:32492552] [PMC:PMC8111697] Related Antibodies: LS-C313066.

Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells. Seon Mee Kang , Hye Sook Jung, Min Jeong Kwon, Soon Hee Lee, Jeong Hyun Park. Annals of Translational Medicine. 2021 May;;9:750. [Full Text Article] [PubMed:34268363] [PMC:PMC8246235] Related Antibodies: LS-C313066.

In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-ß1/SMAD3/NOX4 Cue. Hagar B Abo-Zalam, Rania M Abdelsalam , Rehab F Abdel-Rahman, Mohamed F Abd-Ellah, Mahmoud M Khattab. Molecules (Basel, Switzerland). 2021 Nov;26:6993. [Full Text Article] [PubMed:34834085] [PMC:PMC8618489]

Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis. Yura Lee, Sung-Hee Kim, Haengdueng Jeong, Kwang H Kim, Donghun Jeon, Yejin Cho, Daekee Lee, Ki Taek Nam. Cellular and molecular gastroenterology and hepatology. 2023 May;16:411-429. [Full Text Article] [PubMed:37207801] [PMC:PMC10372905] Related Antibodies: LS-C313066.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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