NOX4

NADPH oxidase 4

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

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Products

Antibodies (54)

ELISA Kits (23)

Proteins (8)

Type

Competitive EIA (3)

Custom (3)

Over-Expression Lysate (2)

Primary (54)

Recombinant (6)

Sandwich (15)

Sandwich CLIA (2)

Target

NOX4 (85)

Reactivity

Human (55)

Mouse (27)

Rat (29)

Bat (3)

Bovine (9)

Chicken (4)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (1)

Horse (3)

Monkey (4)

Orangutan (3)

Pig (5)

Porcine (1)

Primate (5)

Rabbit (6)

Sheep (9)

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Application

IHC (24)

IHC-Fr (1)

IHC-P (12)

WB (49)

Flo (5)

ELISA (22)

ICC (1)

IF (7)

IP (2)

Peptide-ELISA (2)

Host

rabbit (50)

mouse (4)

Product Group

IHCPlus (3)

Isotype

IgG (25)

IgG1 (2)

IgG2b,k (2)

Clonality

monoclonal mc (4)

polyclonal pc (50)

Clone

3H2C4 (1)

3H2G11 (1)

NOX4/1245 (2)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (18)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (6)

BSA-free (1)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Preservative Free (2)

Unconjugated (29)

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Epitope

aa220-392 (8)

aa124-153 (7)

aa100-200 (5)

aa165-214 (4)

C-Terminus (1)

N-Terminus (1)

aa48-97 (1)

aa561-578 (1)

Publications

No (83)

Yes (2)

Sample Type

Cell Lysates (3)

Plasma (10)

Serum (10)

Tissue Homogenates (7)

Tag

6His, N-terminus (1)

6His-B2M, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Rat (2)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

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NOX4 Antibody (aa561-578) LS-C313066

(4.2) Rating

(3) Publication(s)

Antibody:

NOX4 Rabbit anti-Mouse Polyclonal (aa561-578) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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NOX4 Antibody LS-C331983

Antibody:

NOX4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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Human NOX4 (Sandwich ELISA) ELISA Kit - LS-F5867

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

Select

NOX4 Antibody (aa165-214) LS-C201399

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa165-214) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

Rat NOX4 (Sandwich ELISA) ELISA Kit - LS-F5720

(4.1) Rating

(2) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

Select

NOX4 Antibody (aa124-153) LS-C162948

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa124-153) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

IHC-plus™ NOX4 Antibody (aa100-200) LS-B9416

(4.0) Rating

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa100-200) Antibody

Reactivity:

Rabbit, Mouse, Sheep, Bovine, Rat, Pig, Primate, Human

Applications:

ICC, IF, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$460

Select

NOX4 Antibody (aa100-200, Biotin) LS-C83783

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa100-200) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Sheep, Bovine, Rat, Pig, Primate, Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

Select

NOX4 Antibody (aa100-200, DY550) LS-C141600

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa100-200) (DY550) Antibody

Reactivity:

Mouse, Sheep, Bovine, Rat, Primate, Human

Applications:

IHC, IHC-P, WB

Format:

DY550 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY550

• Unconjugated
• Biotin
• DY550

Select

NOX4 Antibody (clone NOX4/1245) LS-C761790

Antibody:

NOX4 Mouse anti-Human Monoclonal (NOX4/1245) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

Select

NOX4 Antibody (clone NOX4/1245, Azide-free, BSA-free) LS-C761792

Antibody:

NOX4 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NOX4/1245) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

Select

Mouse NOX4 (Sandwich ELISA) ELISA Kit - LS-F35896

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NOX4 (Sandwich ELISA) ELISA Kit - LS-F35096

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

IHC-plus™ NOX4 Antibody LS-B12123

(4.0) Rating

Antibody:

NOX4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

NOX4 Antibody (C-Terminus) LS-C46943

Antibody:

NOX4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$379

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NOX4 Antibody (clone 3H2C4) LS-C669289

Antibody:

NOX4 Mouse anti-Human Monoclonal (3H2C4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

NOX4 Antibody (clone 3H2G11) LS-C669233

Antibody:

NOX4 Mouse anti-Human Monoclonal (3H2G11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

NOX4 Antibody (N-Terminus) LS-C353434

Antibody:

NOX4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

NOX4 Antibody LS-C667227

Antibody:

NOX4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

NOX4 Antibody (aa220-392) LS-B13932

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa220-392) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Mouse NOX4 (Sandwich ELISA) ELISA Kit - LS-F5893

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

Select

NOX4 Antibody LS-C396866

Antibody:

NOX4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

NOX4 Antibody (aa124-153) LS-C323405

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa124-153) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

NOX4 Antibody (aa124-153, PE) LS-C264583

Antibody:

NOX4 Rabbit anti-Human Polyclonal (aa124-153) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• PE

• Unconjugated
• PE

Select

NOX4 Antibody LS-C662632

Antibody:

NOX4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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