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NOD2 / CARD15

nucleotide-binding oligomerization domain containing 2

Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.

Gene Name:	nucleotide-binding oligomerization domain containing 2
Synonyms:	NOD2, BLAU, CARD15, ACUG, NOD-like receptor C2, NOD2B, NLRC2, IBD1, CLR16.3, PSORAS1
Target Sequences:	NM_022162 NP_071445.1 Q9HC29

Publications (12)

Crohn's disease and the NOD2 gene: a role for paneth cells. Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nuez G, Keshav S. Gastroenterology. 2003 125:47-57. (IHC-P; Human) [PubMed:12851870]

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S, Nuez G. Gut. 2003 52:1591-7. (IHC-P; Mouse) [PubMed:14570728] [PMC:PMC1773866]

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lcine P, Borg JP, Nuez G. The Journal of biological chemistry. 2005 280:40301-9. [PubMed:16203728]

Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2. Kim TH, Payne U, Zhang X, Iwanaga Y, Davey MP, Rosenbaum JT, Inman RD. Rheumatology international. 2007 27:257-62. [PubMed:17096091]

A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion. Till A, Rosenstiel P, Brutigam K, Sina C, Jacobs G, Oberg HH, Seegert D, Chakraborty T, Schreiber S. Journal of cell science. 2008 121:487-95. [PubMed:18256385]

NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens. Chauhan VS, Sterka DG, Furr SR, Young AB, Marriott I. Glia. 2009 57:414-23. [PubMed:18803303] [PMC:PMC2628967]

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P. Journal of cell science. 2009 122:3522-30. (WB, IP; Human) [PubMed:19759286]

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ, Jewell D, Simmons A. Nature medicine. 2010 16:90-7. [PubMed:19966812]

Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling. von Kampen O, Lipinski S, Till A, Martin SJ, Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P. The Journal of biological chemistry. 2010 285:19921-6. [PubMed:20385562] [PMC:PMC2888403]

Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Hsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schfer H, van Heel D, Li J, Schreiber S, Rosenstiel P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4027-38. (WB; Human) [PubMed:21335489]

Functional expression of NOD2 in freshly isolated human peripheral blood T cells. Marischen L, Wesch D, Oberg HH, Rosenstiel P, Trad A, Shomali M, Grtzinger J, Janssen O, Tchikov V, Schtze S, Kabelitz D. Scandinavian journal of immunology. 2011 74:126-34. [PubMed:21410503]

RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition. Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Hsler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S, Rosenstiel P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:21426-31. (ICC, IHC, WB; Human) [PubMed:23213202] [PMC:PMC3535590]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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