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Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
Gene Name: | nucleolar complex associated 2 homolog (S. cerevisiae) |
Synonyms: | NOC2L, DKFZP564C186, NET7, NET15, NIR, NOC2-like protein, Novel INHAT repressor, Protein NOC2 homolog |
Target Sequences: | NM_015658 NP_056473.2 Q9Y3T9 |
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