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Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Gene Name: | ATP/GTP binding protein 1 |
Synonyms: | AGTPBP1, ATP/GTP binding protein 1, ATP/GTP-binding protein 1, Carboxypeptidase-tubulin, Cytosolic carboxypeptidase 1, KIAA1035, NNA1, Tyrosine carboxypeptidase, Ccp1, Soluble carboxypeptidase, Tubulinyl-Tyr carboxypeptidase |
Target Sequences: | NM_015239 NP_056054.2 Q9UPW5 |
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