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Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).
Gene Name: | N-myristoyltransferase 1 |
Synonyms: | NMT1, Alternative, short form NMT-S, Long form, NMT-L, N-myristoyltransferase 1, NMT, NMT 1, Type I N-myristoyltransferase |
Target Sequences: | NM_021079 NP_066565.1 P30419 |
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