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Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity prefers NAD+, NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+.
Gene Name: | Nicotinamide Nucleotide Adenylyltransferase 2 |
Synonyms: | NMNAT2, C1orf15, KIAA0479, NaMN adenylyltransferase 2, NMN adenylyltransferase 2, PNAT2 |
Target Sequences: | AA084243 NP_055854.1 |
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