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Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
Gene Name: | natural cytotoxicity triggering receptor 3 |
Synonyms: | NCR3, 1C7, CD337 antigen, Activating NK-A1 receptor, Lymphocyte antigen 117, MALS, NKp30, LY117, CD337, NK-p30 |
Target Sequences: | AX367030 AAD18088.1 O14931 |
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