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Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Gene Name: | NFKB inhibitor interacting Ras-like 1 |
Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
Synonyms: | NKIRAS1, Kappa B-Ras protein 1, Kappa B-ras 1, KappaB-Ras1, KBRAS1 |
Target Sequences: | NM_020345 NP_065078.1 Q9NYS0 |
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