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NIX / BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
| Gene Name: | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| Family/Subfamily: | Apoptosis , Not assigned-Other |
| Synonyms: | BNIP3L, NIP3-like protein X, NIP3L, NIX, BNIP3a, BNIP3H |
| Target Sequences: | NM_004331 NP_004322.1 O60238 |
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Products
Antibodies
(42)
Type
Primary
(42)
Target
NIX / BNIP3L
(42)
Reactivity
Human
(41)
Mouse
(20)
Rat
(6)
Bat
(3)
Bovine
(4)
Chimpanzee
(3)
Dog
(3)
Gibbon
(3)
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(3)
Monkey
(3)
Pig
(3)
Rabbit
(3)
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IHC
(25)
IHC-P
(10)
WB
(26)
Flo
(7)
ELISA
(20)
ICC
(9)
IF
(9)
IP
(4)
Peptide-ELISA
(1)
Host
rabbit
(41)
mouse
(1)
Product Group
IHCPlus
(1)
Isotype
IgG
(28)
IgG1,k
(1)
Clonality
monoclonal mc
(1)
polyclonal pc
(41)
Clone
2E11
(1)
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APC Conjugated
(3)
Azide-free
(2)
Biotin Conjugated
(5)
DY488 Conjugated
(1)
DY550 Conjugated
(1)
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(1)
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(4)
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(4)
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(3)
Preservative Free
(1)
Unconjugated
(20)
Epitope
aa52-81
(7)
aa100-150
(6)
aa92-141
(4)
aa1-187
(1)
aa169-219
(1)
aa75-125
(1)
Publications
No
(42)
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
NIX / BNIP3L Rabbit anti-Mouse Polyclonal (aa92-141) Antibody
Mouse
WB
Unconjugated
100 µl/$424
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NIX / BNIP3L Mouse anti-Human Monoclonal (2E11) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$952
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa52-81) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
NIX / BNIP3L Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Human
ICC, IHC, IHC-P
Unconjugated
0.1 ml/$386
NIX / BNIP3L Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
NIX / BNIP3L Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Bovine, Human
ICC, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
NIX / BNIP3L Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Bovine, Human
ICC, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
NIX / BNIP3L Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Bovine, Human
ICC, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa1-187) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
NIX / BNIP3L Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
200 µl/$734
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NIX / BNIP3L Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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