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NIP3 / BNIP3

BCL2/adenovirus E1B 19kDa interacting protein 3

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Gene Name: BCL2/adenovirus E1B 19kDa interacting protein 3
Synonyms: BNIP3, NIP3
Target Sequences: NM_004052 NP_004043.3 Q12983

Publications (1)

1
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Cancer research. 2012 72:3938-47. [PubMed:22719070] Related Antibodies: LS-C98865.

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Products
Proteins (11)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (7)
NIP3 / BNIP3 (11)
No (11)
10His, N-terminus (1)
6His, N-terminus (5)
8His, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (6)
Mouse (3)
Rat (1)
293T Cells (1)
E. coli (7)
HEK 293 Cells (3)
Purified (4)
Low endotoxin level (2)
NIP3 / BNIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus
23.8 kDa
100 µg/$1,801; 20 µg/$1,247
NIP3 / BNIP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
21.4 kDa
20 µg/$150
NIP3 / BNIP3 Protein
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E. coli
His, N-Terminal
19 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315
NIP3 / BNIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
21.6 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
NIP3 / BNIP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
21.4 kDa
100 µg/$494
NIP3 / BNIP3 Protein - Recombinant Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3) by SDS-PAGE
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E. coli
None
45.0kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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HEK 293 Cells
6His, N-terminus
19.2 kDa
200 µl/$283
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HEK 293 Cells
8His, N-terminus
19.2 kDa
100 µg/$298
NIP3 / BNIP3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
21.3 kDa
100 µg/$1,128; 20 µg/$721
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.6 kDa
10 µg/$317; 50 µg/$524
Viewing 1-11 of 11 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).