NGFRAP1 / NADE / Bex

nerve growth factor receptor (TNFRSF16) associated protein 1

The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

NGFRAP1 / NADE / Bex (7)

Publications

No (7)

Tag

GST (2)

His (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

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Human NGFRAP1 / NADE / Bex Protein (Recombinant GST) (Full Length) - LS-G21005

Source:

E. coli

Tag:

GST

Molecular Weight:

40.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NGFRAP1 / NADE / Bex Protein (Recombinant His) (Full Length) - LS-G23055

Source:

Yeast

Tag:

His

Molecular Weight:

15 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human NGFRAP1 / NADE / Bex Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77848

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.8 kDa

Price:

20 µg/$150

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Human NGFRAP1 / NADE / Bex Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77850

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.8 kDa

Price:

20 µg/$150

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NGFRAP1 / NADE / Bex Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102946

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.8 kDa

Price:

100 µg/$494

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Human NGFRAP1 / NADE / Bex Protein (Recombinant GST) (Full Length) - LS-G33232

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.2 kDa

Price:

10 µg/$479; 25 µg/$670

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NGFRAP1 / NADE / Bex Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113989

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

12.8 kDa

Price:

100 µg/$494

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