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Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Gene Name: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
Family/Subfamily: | Apoptosis , not assigned-Other |
Synonyms: | NFKBIA, IkB-alpha, IKBA, IkappaBalpha, MAD3, NF-kappa-B inhibitor alpha, NFKBI, I-kappa-B-alpha, IKB Alpha, MAD-3 |
Target Sequences: | NM_020529 NP_065390.1 P25963 |
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