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NFKBIA / IKB Alpha / IKBA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Family/Subfamily: Apoptosis , not assigned-Other
Synonyms: NFKBIA, IkB-alpha, IKBA, IkappaBalpha, MAD3, NF-kappa-B inhibitor alpha, NFKBI, I-kappa-B-alpha, IKB Alpha, MAD-3
Target Sequences: NM_020529 NP_065390.1 P25963

Publications (1)

1
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C331335.

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Antibodies (141)
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NFKBIA / IKB Alpha / IKBA (170)
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NFKBIA / IKB Alpha / IKBA Antibody - Immunohistochemical analysis of IKB alpha (pS32/S36) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pSer32/Ser36) Antibody
Mouse, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
NFKBIA / IKB Alpha / IKBA Antibody - Immunohistochemistry of paraffin-embedded mouse kidney tissue.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
NFKBIA / IKB Alpha / IKBA Antibody - Anti-IKB Alpha antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:1000.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$515
NFKBIA / IKB Alpha / IKBA Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma with NFKBIA Antibody (S32/36 ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (aa12-41) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NFKBIA / IKB Alpha / IKBA Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
NFKBIA / IKB Alpha / IKBA Antibody - Anti-IKB Alpha antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
NFKBIA / IKB Alpha / IKBA ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$489
NFKBIA / IKB Alpha / IKBA Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Mouse Polyclonal Antibody
Human
IHC
Unconjugated
60 µl/$460
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NFKBIA / IKB Alpha / IKBA Mouse anti-Human Monoclonal (4D4C4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
NFKBIA / IKB Alpha / IKBA Antibody - Immunohistochemical analysis of IKB alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Bovine, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
NFKBIA / IKB Alpha / IKBA Antibody - Immunohistochemical analysis of IKB alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Bovine, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
NFKBIA / IKB Alpha / IKBA Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (aa9-58) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
NFKBIA / IKB Alpha / IKBA Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (aa15-64) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
NFKBIA / IKB Alpha / IKBA Antibody - 1:50 staining human colon carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NFKBIA / IKB Alpha / IKBA Antibody - 1:100 staining mouse gastric tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pSer32,pSer36) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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NFKBIA / IKB Alpha / IKBA Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$256; 100 µl/$412
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Monoclonal (Preservative Free) (056) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
NFKBIA / IKB Alpha / IKBA Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using I?B-a (Phospho-Ser32/Ser36) antibody.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pSer32/Ser36) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
NFKBIA / IKB Alpha / IKBA Antibody - 1:100 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pTyr305) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NFKBIA / IKB Alpha / IKBA Antibody - Western blot of I kappaB- alpha phosphorylation expression in COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pSer32/Ser36) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
NFKBIA / IKB Alpha / IKBA Antibody - IKB alpha antibody detects NFKBIA protein at nucleus on U251 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U251 xenograft. IKB alpha antibody dilution:1:500.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (aa1-317) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
NFKBIA / IKB Alpha / IKBA Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IkappaB-alpha (Phospho-Ser32/Ser36) Antibody. The picture on the right is blocked with the phospho peptide.
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NFKBIA / IKB Alpha / IKBA Rabbit anti-Human Polyclonal (pSer32/Ser36) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 170 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).