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NFIL3
nuclear factor, interleukin 3 regulated
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death.
| Gene Name: | nuclear factor, interleukin 3 regulated |
| Synonyms: | NFIL3, E4 promoter-binding protein 4, E4BP4, NF-IL3A, NFIL3A, IL3BP1 |
| Target Sequences: | NM_005384 NP_005375.2 Q16649 |
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