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Neuropeptide Y / NPY

neuropeptide Y

Neuropeptide Y / NPY is a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.

Gene Name: neuropeptide Y
Family/Subfamily: Pancreatic hormone , not assigned-Pancreatic hormone
Synonyms: NPY, Pro-neuropeptide Y, Neuropeptide Y, PYY4
Target Sequences: NM_000905 NP_000896.1 P01303

Publications (1)

1
Central anorexigenic actions of bile acids are mediated by TGR5. Alessia Perino, Laura A Velázquez-Villegas, Nadia Bresciani, Yu Sun, Qingyao Huang, Valérie S Fénelon, Ashley Castellanos-Jankiewicz, Philippe Zizzari, Giuseppe Bruschetta, Sungho Jin, Aiste Baleisyte, Antimo Gioiello, Roberto Pellicciari, Julijana Ivanisevic, Bernard L Schneider, Sabrina Diano, Daniela Cota, Kristina Schoonjans. Nature metabolism. 2021 May;3:595-603. [Full Text Article] [PubMed:34031591] [PMC:PMC7610881]

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Proteins (9)
Recombinant (8)
Synthetic Peptide (1)
Neuropeptide Y / NPY (9)
No (9)
6His, C-terminus (2)
GST (2)
GST, N-terminus (1)
His, N-Terminal (1)
His-GST (2)
Human (8)
Rat (1)
E. coli (3)
Human Cells (1)
Mammalian Cells (1)
Synthetic (1)
Wheat Germ Extract (3)
Purified (3)
Low endotoxin level (2)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
9.1kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Neuropeptide Y / NPY Protein - Recombinant Neuropeptide Y By SDS-PAGE
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E. coli
His-GST
40.3 kDa
50 µg/$362; 10 µg/$268; 200 µg/$722; 100 µg/$577; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
Neuropeptide Y / NPY Protein - Recombinant Neuropeptide Y By SDS-PAGE
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E. coli
His-GST
34.9 kDa
10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107
Neuropeptide Y / NPY Protein - 12.5% SDS-PAGE of human NPY stained with Coomassie Blue
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Wheat Germ Extract
GST
36.41 kDa
10 µg/$479; 25 µg/$670
Neuropeptide Y / NPY Protein - 12.5% SDS-PAGE of human NPY stained with Coomassie Blue
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Wheat Germ Extract
GST
37.3 kDa
10 µg/$479; 25 µg/$670
Select
Synthetic
None
4271.8 Da
0.1 mg/$341
Neuropeptide Y / NPY Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
9.1 kDa
10 µg/$288; 50 µg/$436
Neuropeptide Y / NPY Protein
Select
E. coli
His, N-Terminal
8 kDa
50 µg/$419
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).