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NEU1 / NEU

sialidase 1 (lysosomal sialidase)

NEU1 / NEU is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Gene Name: sialidase 1 (lysosomal sialidase)
Synonyms: NEU1, Acetylneuraminyl hydrolase, G9 gene encoding sialidase, G9 sialidase, Exo-alpha-sialidase, Neu, Sialidase-1, Lysosomal sialidase, SIAL1, N-acetyl-alpha-neuraminidase 1, NANH
Target Sequences: NM_000434 NP_000425.1 Q99519

Publications (1)

1
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis. Luzina IG, Lockatell V, Hyun SW, Kopach P, Kang PH, Noor Z, Liu A, Lillehoj EP, Lee C, Miranda-Ribera A, Todd NW, Goldblum SE, Atamas SP. American journal of physiology. Lung cellular and molecular physiology. 2016 May;310:L940-54. [Full Text Article] [PubMed:26993524] [PMC:PMC4896097]

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
NEU1 / NEU (9)
No (9)
6His, C-terminus (2)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.27kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
NEU1 / NEU Protein - Active Neuraminidase (NEU) by WB
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E. coli
His, N-Terminal
46kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
NEU1 / NEU Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
45.47 kDa
20 µg/$150
NEU1 / NEU Protein - Purified recombinant protein NEU1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
40.2 kDa
20 µg/$1,107
NEU1 / NEU Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.47 kDa
100 µg/$494
NEU1 / NEU Protein - Active Neuraminidase (NEU) by WB
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E. coli
His, N-Terminal
26kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.3 kDa
10 µg/$344; 50 µg/$584
NEU1 / NEU Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).