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NEU1 / NEU
sialidase 1 (lysosomal sialidase)
NEU1 / NEU is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
| Gene Name: | sialidase 1 (lysosomal sialidase) |
| Synonyms: | NEU1, Acetylneuraminyl hydrolase, G9 gene encoding sialidase, G9 sialidase, Exo-alpha-sialidase, Neu, Sialidase-1, Lysosomal sialidase, SIAL1, N-acetyl-alpha-neuraminidase 1, NANH |
| Target Sequences: | NM_000434 NP_000425.1 Q99519 |
Publications (1)
1
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis. Luzina IG, Lockatell V, Hyun SW, Kopach P, Kang PH, Noor Z, Liu A, Lillehoj EP, Lee C, Miranda-Ribera A, Todd NW, Goldblum SE, Atamas SP. American journal of physiology. Lung cellular and molecular physiology. 2016 May;310:L940-54. [Full Text Article]
[PubMed:26993524]
[PMC:PMC4896097]
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NEU1 / NEU
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NEU1 / NEU Rabbit anti-Human Polyclonal (aa172-221) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
NEU1 / NEU Rabbit anti-Human Polyclonal (aa172-221) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
NEU1 / NEU Rabbit anti-Human Polyclonal (aa172-221) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
NEU1 / NEU Rabbit anti-Human Polyclonal (aa172-221) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
NEU1 / NEU Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NEU1 / NEU Mouse anti-Human Monoclonal (3F9) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
NEU1 / NEU Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
NEU1 / NEU Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
NEU1 / NEU Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.27kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NEU1 / NEU Rabbit anti-Human Polyclonal (aa188-214) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NEU1 / NEU Mouse anti-Human Monoclonal (OTI3B8) Antibody
Human
WB
Unconjugated
100 µl/$434
NEU1 / NEU Mouse anti-Human Monoclonal (OTI3B3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NEU1 / NEU Mouse anti-Human Monoclonal (aa48-315) (Carrier-free) (OTI3B3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NEU1 / NEU Mouse anti-Human Monoclonal (OTI3D4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NEU1 / NEU Mouse anti-Human Monoclonal (aa48-315) (Carrier-free) (OTI3D4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
E. coli
His, N-Terminal
46kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
NEU1 / NEU Mouse anti-Human Monoclonal (aa46-415) (1D4B) Antibody
Human
IP, WB
Unconjugated
100 µg/$896
NEU1 / NEU Mouse anti-Human Monoclonal (aa48-315) (OTI3H2) Antibody
Human
WB
Unconjugated
100 µl/$434
NEU1 / NEU Mouse anti-Human Monoclonal (aa48-315) (OTI3H4) Antibody
Human
WB
Unconjugated
100 µl/$434
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