NEP / DDR1

discoidin domain receptor tyrosine kinase 1

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

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Products

Proteins (18)

Type

Over-Expression Lysate (6)

Recombinant (12)

Target

NEP / DDR1 (18)

Publications

No (18)

Tag

Fc (2)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His,C-terminus (1)

His-GST (2)

Myc-DDK (Flag) (8)

Species

Human (10)

Mouse (3)

Rat (2)

Source

293T Cells (3)

Baculovirus (2)

E. coli (1)

HEK 293 Cells (6)

Human Cells (4)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (7)

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Mouse NEP / DDR1 Protein (Recombinant His) (Met1-Thr414) - LS-G98756

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.4 kDa

Price:

100 µg/$721

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Human NEP / DDR1 Protein (Recombinant His, N-Terminal) (aa568-829) - LS-G13163

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75772

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.9 kDa

Price:

20 µg/$215

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Human NEP / DDR1 Protein (Recombinant His) (Met1-Thr416) - LS-G97376

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.7 kDa

Price:

100 µg/$721

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Rat NEP / DDR1 Protein (Recombinant His,C-terminus) (Met1-Thr413) - LS-G138195

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.3 kDa

Price:

100 µg/$721

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Human NEP / DDR1 Protein (Recombinant GST) (Full Length) - LS-G27710

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

119.79 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse NEP / DDR1 Protein (Recombinant His-GST) (Leu444-Val874) - LS-G98127

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75.8 kDa

Price:

50 µg/$707

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Human NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75771

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97 kDa

Price:

20 µg/$150

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Human NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75770

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

20 µg/$215

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Human NEP / DDR1 Protein (Recombinant His-GST) (Arg444-Val913) - LS-G97375

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80 kDa

Price:

50 µg/$707

Select

Human NEP / DDR1 Protein (Recombinant GST, N-terminus) (aa278-377) - LS-G57959

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NEP / DDR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65543

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

20 µg/$1,107

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Human NEP / DDR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65542

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.9 kDa

Price:

20 µg/$1,107

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NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114240

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

100.9 kDa

Price:

100 µg/$710

Select

NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114241

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

101.6 kDa

Price:

100 µg/$710

Select

NEP / DDR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99603

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97 kDa

Price:

100 µg/$494

Select

Mouse NEP / DDR1 Protein (Recombinant Fc) (Met1-Thr414) - LS-G98757

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71 kDa

Price:

100 µg/$721

Select

Rat NEP / DDR1 Protein (Recombinant Fc) (Met1-Thr413) - LS-G98378

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

70.9 kDa

Price:

100 µg/$721

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