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NEK6

NIMA-related kinase 6

NEK6 encodes a NEK type protein kinase, which contains a C-terminal NIMA-like catalytic domain. The protein is believed to regulate chromatin condensation in mammalian cells via phosphorylation of histones H1 and H3, and it has been shown to phosphorylate ribosomal S6 protein kinase (S6K1) and serum and glucocorticoid induced protein kinase (SGK1), which regulate diverse cellular processes. The protein also has been shown to bind NEK9, another NIMA-related kinase which regulates chromosome alignment and segregation. At least three mRNA transcripts have been identified, 1.6-, 2.6-, and 9.5-kb. The NEK6 gene is localized to 9q33-34, a region at which the loss of heterozygosity is associated with transitional cell carcinomas.

Gene Name: NIMA-related kinase 6
Family/Subfamily: Protein Kinase , NEK
Synonyms: NEK6, NIMA-related kinase 6, Protein kinase SID6-1512, NimA-related protein kinase 6, SID6-1512
Target Sequences: NM_014397 NP_055212.2 Q9HC98

Publications (1)

1
Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. Takeno A, Takemasa I, Doki Y, Yamasaki M, Miyata H, Takiguchi S, Fujiwara Y, Matsubara K, Monden M. British journal of cancer. 2008 99:1307-15. [PubMed:18827816] [PMC:PMC2570518]

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Products
Proteins (17)
Over-Expression Lysate (12)
Recombinant (5)
NEK6 (17)
No (17)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (15)
Human (11)
293T Cells (6)
HEK 293 Cells (9)
Wheat Germ Extract (2)
Purified (1)
NEK6 Protein - 12.5% SDS-PAGE of human NEK6 stained with Coomassie Blue
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Wheat Germ Extract
GST
59.95 kDa
10 µg/$479; 25 µg/$670
NEK6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.7 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.7 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$150
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
100 µg/$494
NEK6 Protein - Purified recombinant protein NEK6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.7 kDa
20 µg/$1,107
NEK6 Protein - Purified recombinant protein NEK6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$1,107
NEK6 Protein - Purified recombinant protein NEK6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$1,107
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
100 µg/$494
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.7 kDa
100 µg/$494
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.7 kDa
100 µg/$494
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
100 µg/$494
NEK6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
100 µg/$494
Viewing 1-17 of 17 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).