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NEK2
NIMA-related kinase 2
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
| Gene Name: | NIMA-related kinase 2 |
| Family/Subfamily: | Protein Kinase , NEK |
| Synonyms: | NEK2, NIMA-related kinase 2, NEK2A, HsPK21, NimA-like protein kinase 1, NLK1, HSPK 21, NimA-related protein kinase 2 |
| Target Sequences: | NM_002497 NP_002488.1 P51955 |
Publications (4)
1
A New 2-Step Acceleration Protocol Using a Histone Deacetylase Inhibitor to Generate Insulin-Producing Cells From Adipose-Derived Mesenchymal Stem Cells. Ikemoto T, Feng R, Shimada M, Saito Y, Iwahashi S, Morine Y, Imura S. Pancreas. 2018 April;47:477-481. (Human)
[Full Text Article]
[PubMed:29517636]
[PMC:PMC5865483]
Related Antibodies: LS-B129.
2
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells. Ohta S, Ikemoto T, Wada Y, Saito Y, Yamada S, Imura S, Morine Y, Shimada M. Science advances. 2019 December;9:18731. [Full Text Article]
[PubMed:31822724]
[PMC:PMC6904733]
Related Antibodies: LS-B129.
3
The Differences in the Characteristics of Insulin-producing Cells Using Human Adipose-tissue Derived Mesenchymal Stem Cells from Subcutaneous and Visceral Tissues. Wada Y, Ikemoto T, Morine Y, Imura S, Saito Y, Yamada S, Shimada M. Science advances. 2019 September;9:13204. [Full Text Article]
[PubMed:31519950]
[PMC:PMC6744430]
Related Antibodies: LS-B129.
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NEK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$515
NEK2 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
NEK2 Rabbit anti-Human Polyclonal (aa396-426) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
NEK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
NEK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
NEK2 Rabbit anti-Human Polyclonal (aa130-179) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NEK2 Rabbit anti-Human Polyclonal (aa130-179) (HRP) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NEK2 Rabbit anti-Human Polyclonal (aa130-179) (Biotin) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NEK2 Rabbit anti-Human Polyclonal (aa130-179) (FITC) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) Antibody
Hamster, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa1165-1196) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa1-135) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NEK2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
NEK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$357
NEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NEK2 Rabbit anti-Human Polyclonal (aa350-382) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa350-382) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa350-382) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa350-382) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NEK2 Rabbit anti-Human Polyclonal (aa396-426) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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