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NEIL2

nei endonuclease VIII-like 2 (E. coli)

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

Gene Name: nei endonuclease VIII-like 2 (E. coli)
Synonyms: NEIL2, Nei homolog 2, NEH2, Nei like 2, Nei like 2 (E. coli), DNA glycosylase/AP lyase Neil2, Endonuclease 8-like 2, Endonuclease VIII-like 2, Nei-like protein 2, NEI2
Target Sequences: Q969S2 Q969S2

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Products
Antibodies (17)
Primary (17)
NEIL2 (17)
Human (17)
Mouse (4)
Rat (7)
Bat (3)
Bovine (4)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (4)
IHC (1)
WB (17)
DB (1)
ELISA (7)
Peptide-ELISA (1)
rabbit (15)
mouse (2)
IgG (7)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (15)
2626C2a (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (9)
aa67-96 (7)
aa64-113 (4)
Internal (1)
No (17)
NEIL2 Antibody - 1:100 staining mouse pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NEIL2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NEIL2 Antibody - Western blot analysis of NEIL2 expression in HEK293T (A); PC12 (B) whole cell lysates.
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NEIL2 Rabbit anti-Human Polyclonal (Internal) Antibody
Bovine, Rat, Human, Monkey
WB
Unconjugated
100 µl/$299
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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NEIL2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
NEIL2 Antibody - Detection of NEIL2 by Western blot. Samples: Whole cell lysate from human HeLa (H, 25 ug) , mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. Predicted molecular weight: 36 kDa
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NEIL2 Mouse anti-Human Monoclonal (2626C2a) Antibody
Mouse, Rat, Human
DB, WB
Unconjugated
100 µg/$486
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NEIL2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$786
NEIL2 Antibody - Western blot of NEIL2 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: PC12 whole cell lysate.
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NEIL2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
NEIL2 Antibody - NEIL2 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The NEIL2 antibody detected the NEIL2 protein (arrow).
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NEIL2 Rabbit anti-Human Polyclonal (aa67-96) Antibody
Human
WB
Unconjugated
400 µl/$393
NEIL2 Antibody - NEIL2 antibody Western Blot of THP-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NEIL2 Rabbit anti-Human Polyclonal (aa64-113) Antibody
Human
WB
Unconjugated
100 µl/$424
NEIL2 Antibody - NEIL2 antibody Western Blot of THP-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NEIL2 Rabbit anti-Human Polyclonal (aa64-113) (HRP) Antibody
Dog, Guinea pig, Bovine, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
NEIL2 Antibody - NEIL2 antibody Western Blot of THP-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NEIL2 Rabbit anti-Human Polyclonal (aa64-113) (Biotin) Antibody
Dog, Guinea pig, Bovine, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
NEIL2 Antibody - NEIL2 antibody Western Blot of THP-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NEIL2 Rabbit anti-Human Polyclonal (aa64-113) (FITC) Antibody
Dog, Guinea pig, Bovine, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).