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NEFH / NF-H

neurofilament, heavy polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Gene Name: neurofilament, heavy polypeptide
Synonyms: NEFH, 200 kDa neurofilament protein, KIAA0845, NFH, NF-H
Target Sequences: NM_021076 NP_066554.2 P12036

Publications (3)

1
Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:981-90. [PubMed:16421318]
2
Caveolin-1 deficiency increases cerebral ischemic injury. Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM, Lisanti MP. Circulation research. 2007 100:721-9. [PubMed:17293479]
3
Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Louis ED, Ma K, Babij R, Corts E, Liem RK, Vonsattel JP, Faust PL. Neuroscience letters. 2012 518:49-54. (IHC, WB; Human) [PubMed:22561033] [PMC:PMC3364538]

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ELISA Kits (12)
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NEFH / NF-H (12)
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Rat (4)
Pig (1)
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Cerebrospinal Fluid (1)
Plasma (10)
Serum (10)
Tissue Homogenates (6)
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$783
NEFH / NF-H ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
NEFH / NF-H ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cerebrospinal Fluid, Plasma, Serum
1 Plate/$897
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).