NEDF / VPS24

charged multivesicular body protein 3

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NEDF / VPS24 (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human NEDF / VPS24 Protein (Recombinant GST) (Full Length) - LS-G33860

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NEDF / VPS24 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88919

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

20 µg/$150

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Human NEDF / VPS24 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71128

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

20 µg/$1,107

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NEDF / VPS24 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112877

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.9 kDa

Price:

100 µg/$494

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Human NEDF / VPS24 Protein (Recombinant His) - LS-G1323

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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