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NEDD8
neural precursor cell expressed, developmentally down-regulated 8
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
| Gene Name: | neural precursor cell expressed, developmentally down-regulated 8 |
| Synonyms: | NEDD8, NEDD-8, Neddylin, Ubiquitin-like protein Nedd8 |
| Target Sequences: | NM_006156 NP_006147.1 Q15843 |
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