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Nectin-1 / PVRL1 is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Gene Name: | Poliovirus receptor-related 1 (herpesvirus entry mediator C) |
Synonyms: | PVRL1, CD111 antigen, CLPED1, CD111, Herpesvirus entry mediator C, Herpes virus entry mediator C, Herpesvirus Ig-like receptor, Nectin 1, OFC7, Poliovirus receptor-like 1, PRR, Nectin-1, PRR1, PVRR, PVRR1, SK-12, ED4, HIgR, HVEC |
Target Sequences: | NM_002855 NP_002846.3 Q15223 |
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