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The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain. The predicted protein is a 116 amino acid peptide with a molecular weight of 13.34 kDa. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The deduced peptide belongs to the 7 component-containing, water soluble ""iron-sulfur protein"" (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. The predicted secondary structure is primarily alpha helix, but the carboxy-terminal half of the protein has high potential to adopt a coiled-coil form. The amino-terminal part contains a putative beta sheet rich in hydrophobic amino acids that may serve as mitochondrial import signal.
Gene Name: | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 |
Synonyms: | NDUFA5, B13, Complex I 13kDa subunit B, CI-13KD-B, CI-13kB, Complex I subunit B13, Complex I-13kD-B, NUFM, Type I dehydrogenase, Ubiquinone reductase, UQOR13 |
Target Sequences: | NM_005000 NP_004991.1 Q16718 |
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