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Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Gene Name: | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Synonyms: | NDUFA13, B16.6, CGI-39, CI-B16.6, Complex I-B16.6, GRIM-19, GRIM19, CDA016, Complex I B16.6 subunit |
Target Sequences: | NM_015965 |
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